Seasonal variation and stability of matrix metalloproteinase-9 activity and tissue inhibitor of matrix metalloproteinase-1 with storage at-80 degrees C

作者：Tarr G P; Williams M J A; Phillips L V; van Rij A M; Jones G T^*

来源：Clinical Biochemistry, 2011, 44(16): 1346-1348.

DOI：10.1016/j.clinbiochem.2011.08.1139

• Matrix metalloproteainase
• Tissue inhibitor of matrix metalloproteinase
• Human
• Plasma
• Stability
• Seasonal variation

Objective: To determine whether active matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 displayed seasonal variation and were stable in storage.
Methods: Plasma active MMP-9 and TIMP-1 were measured at three time-points in 163 individuals.
Result: There was no evidence for seasonal variation or declining levels for up to three years of storage at -80 degrees C.
Conclusion: Active MMP-9 and TIMP-1 appear to be stable seasonally, and in storage for at least three years.

• 出版日期2011-11