Aquaporins in cancer

作者：Ribatti Domenico^*; Ranieri Girolamo; Annese Tiziana; Nico Beatrice

来源：Biochimica et Biophysica Acta-General Subjects, 2014, 1840(5): 1550-1553.

DOI：10.1016/j.bbagen.2013.09.025

• Angiogenesis
• Aquaporins
• Edema
• Glioblastoma
• Tumor growth

Background: The aquaporins(AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration.
Scope of the review: This review article summarizes our knowledge concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process.
Major conclusions: Tumor cells types express AQPs and a positive correlation exists between histological tumor grade and the AQP expression. Moreover, AQPs are involved also in tumor edema formation and angiogenesis in several solid and hematological tumors.
General significance: AQPs inhibition in endothelial and tumor cells might limit tumor growth and spread, suggesting a potential therapeutic use in the treatment of tumors. This article is part of a Special Issue entitled Aquaporins.

• 出版日期2014-5