Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is not Related to Clinical Classifications

作者：Kiszalkiewicz Justyna; Piotrowski Wojciech J; Pastuszak Lewandoska Dorota; Gorski Pawel; Antczak Adam; Gorski Witold; Domanska Senderowska Daria; Migdalska Sek Monika; Czarnecka Karolina H; Nawrot Ewa; Brzezianska Lasota Ewa^*

来源：Inflammation, 2016, 39(4): 1302-1309.

DOI：10.1007/s10753-016-0362-y

• pulmonary sarcoidosis
• expression
• COX-2
• biomarkers

Elevated COX-2 activity is associated with the development of chronic lung diseases leading to bronchial obstruction, including sarcoidosis. The aim of the study was to examine expression pattern of COX-2 messenger RNA (mRNA). Expression was performed by q-PCR method in bronchoalveolar lavage (BAL) cells and peripheral blood (PB) lymphocytes in sarcoidosis patients (n = 61) and control group (n = 30). Analysis of COX-2 mRNA expression level in BAL fluid and PB revealed downregulation in sarcoidosis and control groups. In PB lymphocytes, the statistically significant difference between patients and controls was observed (P = 0.003, Mann-Whitney U test), with higher expression in patients. There were no statistically significant differences between patients without and with parenchymal involvement (stages I vs. II-IV), between patients with acute vs. insidious onset of disease and between patients with abnormal vs. normal spirometry (P > 0.05, Mann-Whitney U test). Results suggest that expression of COX-2 mRNA in patients with pulmonary sarcoidosis is not related to clinical classifications.

• 出版日期2016-8