Deconstructing and reconstructing the mouse and human early embryo

作者：Shahbazi Marta N^*; Zernicka Goetz Magdalena^*

来源：Nature Cell Biology, 2018, 20(8): 878-887.

DOI：10.1038/s41556-018-0144-x

The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.

• 出版日期2018-8