Using the same organocatalyst for asymmetric synthesis of both enantiomers of glutamic acid-derived Ni(II) complexes via 1,4-additions of achiral glycine and dehydroalanine Schiff base Ni(II) complexes

作者：Belokon Yuri N^*; Gugkaeva Zalina T; Hakobyan Karine V; Maleev Victor I; Moskalenko Margarita A; Khrustalev Victor N; Saghyan Ashot S; Tsaloev Alan T; Babievsky Kiryl K

来源：Amino Acids, 2012, 43(1): 299-308.

DOI：10.1007/s00726-011-1076-y

• gamma-Carboxyglutamic acid
• Glutamic acid
• Asymmetric organocatalysis
• Michael addition

(S)- and (R)-BIMBOL were efficient PT catalysts of asymmetric Michael addition of prochiral Ni-PBP-Gly (1) to acrylic esters and malonic esters to Ni-PBP-Delta-Ala (2) correspondingly. The salient feature of the catalysis is opposite configurations of Glu prepared via the two paths with BIMBOL of the same configuration and a perspective novel catalytic procedure for the synthesis of Gla derivatives.

• 出版日期2012-7