Pull-Push Neuromodulation of LTP and LTD Enables Bidirectional Experience-Induced Synaptic Scaling in Visual Cortex

作者：Huang, ShiYong; Trevino, Mario; He, Kaiwen; Ardiles, Alvaro; de Pasquale, Roberto; Guo, Yatu; Palacios, Adrian; Huganir, Richard; Kirkwood, Alfredo^*

来源：Neuron, 2012, 73(3): 497-510.

DOI：10.1016/j.neuron.2011.11.023

• LONG-TERM POTENTIATION
• TIMING-DEPENDENT PLASTICITY
• HIPPOCAMPAL CA1 REGION
• CORTICAL PLASTICITY
• INHIBITORY AUTOPHOSPHORYLATION
• ADRENERGIC MODULATION
• PREFRONTAL CORTEX
• DEPRESSION
• RECEPTORS
• SYNAPSES

Neuromodulatory input, acting on G protein-coupled receptors, is essential for the induction of experience-dependent cortical plasticity. Here we report that G-coupled receptors in layer II/III of visual cortex control the polarity of synaptic plasticity through a pull-push regulation of LTP and LTD. In slices, receptors coupled to Gs promote LTP while suppressing LTD; conversely, receptors coupled to Gq11 promote LTD and suppress LTP. In vivo, the selective stimulation of Gs- or Gq11-coupled receptors brings the cortex into LIP-only or LTD-only states, which allows the potentiation or depression of targeted synapses with visual stimulation. The pull-push regulation of LTP/LTD occurs via direct control of the synaptic plasticity machinery and it is independent of changes in NMDAR activation or neuronal excitability. We propose these simple rules governing the pull-push control of LTP/LTD form a general metaplasticity mechanism that may contribute to neuromodulation of plasticity in other cortical circuits.

• 出版日期2012-2-9
• 单位天津市眼科医院; 天津医科大学