Antipsychotics%26apos; effects on blood levels of cytokines in schizophrenia: A meta-analysis

作者：Tourjman Valerie; Kouassi Edouard^*; Koue Marie Eve; Rocchetti Matteo; Fortin Fournier Simon; Fusar Poli Paolo; Potvin Stephane

来源：Schizophrenia Research, 2013, 151(1-3): 43-47.

DOI：10.1016/j.schres.2013.10.011

• Schizophrenia
• Antipsychotic drugs
• Cytokines
• Inflammation

Objectives: Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined. %26lt;br%26gt;Methods: A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment. %26lt;br%26gt;Results: We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1 beta and interferon-gamma. %26lt;br%26gt;Conclusions: These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.

• 出版日期2013-12