An Ultra Performance Liquid Chromatography-tandem mass spectrometry method for Plasma and cerebrospinal fluid pharmacokinetics of rhubarb decoction after blood-brain barrier disruption in patients with traumatic brain injury

作者：Yang Wang; Rong Fan; Jiekun Luo; Tao Tang; Zhihua Xing; Zian Xia; Weijun Peng; Wenzhu Wang; Xi Huang

来源：中西医结合实验医学专业委员会、湖南省中西医结合神经科专业委员会, China,Hunan,Changsha.

• An Ultra Performance Liquid Chromatography-tandem mass spectrometry method for Plasma and cerebrospinal fluid pharmacokinetics of rhubarb decoction after blood-brain barrier disruption in patients wit

<正>Blood brain barrier(BBB)opening may provide a chance through which rhein(found in Chinese herb rhubarb)that do not normally cross the barrier is able to do so.An UPLC-MS/MS method was established to determine rhein in biofluids(plasma and CSF)of traumatic brain injury(TBI)patients under the state...

• 出版日期2015
• 单位南京中医药大学