Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats: Involvement of MAPK signal pathway

作者：Yu, Xing; Wang, Lin-na; Ma, Lin; You, Ran; Cui, Ran; Ji, De; Wu, Yue; Zhang, Chun-feng; Yang, Zhong-lin; Ji, Hui^*

来源：Pharmacology Biochemistry and Behavior, 2012, 101(3): 479-486.

DOI：10.1016/j.pbb.2012.02.014

• Alzheimer's disease
• Akebia saponin D (ASD)
• Cognitive impairment
• Cholinergic deficit
• Ibotenic acid
• Mitogen-activated protein kinase (MAPK)

Cholinergic deficit is one of the most remarkable symptoms and plays an important role in Alzheimer's disease. In the present study, the protective effects of Akebia saponin D (ASD) on learning and memory impairments induced by excitatory neurotoxin ibotenic acid injection were examined in vivo. Our findings suggest that ASD (90 mg/kg, p.o.) would exert a rescue effect on rats both in behavioral performances in Morris water maze and Y maze and cholinergic functions detected by chemical methods. We further investigated in the hippocampus and found ASD could regulate apoptosis-related proteins expression following ibotenic acid injection. Additionally, mitogen-activated protein kinase (MAPK) family phosphorylations were inhibited after ASD treatment, implicating that the MAPK signaling pathway could be involved in the mechanism underlying neuroprotection of ASD against ibotenic acid-induced excitotoxicity.

• 出版日期2012-5
• 单位天然药物活性组分与药效国家重点实验室; 中国药科大学