A Perspective - can copper complexes be developed as a novel class of therapeutics?

作者:Wehbe Mohamed*; Leung Ada W Y; Abrams Michael J; Orvig Chris; Bally Marcel B
来源:Dalton Transactions, 2017, 46(33): 10758-10773.
DOI:10.1039/c7dt01955f

摘要

Although copper-ligand complexes appear to be promising as a new class of therapeutics, other than the family of copper(II) coordination compounds referred to as casiopeinas these compounds have yet to reach the clinic for human use. The pharmaceutical challenges associated with developing copper-based therapeutics will be presented in this article along with a discussion of the potential for high-throughput chemistry, computer-aided drug design, and nanotechnology to address the development of this important class of drug candidates.

  • 出版日期2017-9-7