MQD - Multiplex-Quadrature Detection in Multi-Dimensional NMR

作者：Schlagnitweit Judith; Hornicakova Michaela; Zuckerstaetter Gerhard; Mueller Norbert

来源：ChemPhysChem, 2012, 13(1): 342-346.

DOI：10.1002/cphc.201100525

• accelerated acquisition
• axial peak suppression
• multi-dimensional NMR
• multiplex-phase cycling
• NMR spectroscopy

With multiplex-quadrature detection (MQD) the tasks of coherence selection and quadrature separation in N-dimensional heteronuclear NMR experiments are merged. Thus the number of acquisitions required to achieve a desired resolution in the indirect dimensions is significantly reduced. The minimum number of transients per indirect data point, which have to be combined to give pure-phase spectra, is thus decreased by a factor (3/4)N-1. This reduction is achieved without adjustable parameters. We demonstrate the advantage by MQD 3D HNCO and HCCH-TOCSY spectra affording the same resolution and the same per-scan sensitivity as standard phase-cycled ones, but obtained in only 56?% of the usual time and by resolution improvements achieved in the same amount of time.

• 出版日期2012-1-16