New dammarane and ursane-type triterpenoids from the flower of Ixora coccinea Linn

作者：Ikram Ambreen; Versiani Muhammad Ali^*; Khatoon Amna; Ahmed Salman Khalid; Sattar Samina Abdul; Faizi Shaheen

来源：Natural Product Research, 2016, 30(7): 768-775.

DOI：10.1080/14786419.2015.1063056

• dammarane triterpenoid
• ixorene isovalerate
• ixorene 3
• 8-dimethyloctanoate
• cytotoxic activity
• antioxidant activity

Two new esters of dammarane triterpenoids ixorene isovalerate (1), ixorene 3,8-dimethyloctanoate (2) and a new ursane-type triterpenoids Ixoroid acid (3) were isolated from the methanolic extract of flowers of Ixora coccinea Linn., along with the three known constituents. The structures of compounds 1 and 3 were elucidated on the basis of extensive 1D,2D NMR studies and mass spectrometry as 17-dammara-12,20-diene-3-isovelarate and 3-hydroxy-18-urs-12ene-29-oic acid, respectively, whereas 2 was identified as 17-dammara-12,20-diene-3-3,8-dimethyloctanoate through H-1 NMR and mass spectral data. Compounds 1, 2, 4 and 5 were evaluated for their in vitro cytotoxic activity, which exhibited weak activity against the 3T3, PC3 and HeLa cell lines with the IC50 value >30M. Antioxidant results of 1 - 5 revealed that only compound 5 showed antioxidant activity in DPPH radical scavenging inhibition with the IC50 1.31x10(-6)+/- 0.005m mL(-1). Both activities are the first records of these isolated compounds from the flowers of Ixora coccinea Linn.

• 出版日期2016-4-2