Associations among periostin gene polymorphisms, clinical parameters and heart failure: a case-control study in 1104 Chinese individuals

作者：Wang Fangfang; Song Ying; Jiang Ye; Yang Cuan; Ding Zhijian^*

来源：Journal of Cardiovascular Medicine, 2011, 12(7): 469-474.

DOI：10.2459/JCM.0b013e328347e48c

• heart failure
• hyperlipidemia
• periostin gene
• rs1028728
• rs3829365
• single nucleotide polymorphism
• smoking

Aims To determine the associations among periostin gene polymorphisms, clinical parameters and heart failure in a Chinese population.
Methods In total, 464 patients with heart failure and 640 control individuals were included in this study. rs3829365 and rs1028728 were genotyped through PCR and restriction fragment length polymorphism. Multivariate logistic regression was employed to analyze the independent strength of association among clinical parameters, genotypes and heart failure.
Results rs3829365 was associated with heart failure (P = 0.043), whereas rs1028728 was not (P = 0.188). After adjusting for age, sex, hypertension, diabetes mellitus, smoking and hypertriglyceridemia in multivariate logistic regression, we found that CG or GG of rs3829365 [P = 0.015, odds ratio (OR) = 1.88] was an independent risk factor for heart failure and that CG or GG of rs3829365 (P = 0.039, OR = 0.94) and AT or TT of rs1028728 (P = 0.011, OR = 0.68) were significantly protective factors for heart failure in patients who smoked and in patients with hypertriglyceridemia, respectively. Moreover, heart failure in patients with CG or GG genotype of rs3829365 tended to be more severe than in those with CC genotype.
Conclusion These findings suggest that rs3829365 of the periostin gene may be helpful to determine the susceptibility to, and severity of, heart failure. The interactions between rs3829365 and smoking and between rs1028728 and hypertriglyceridemia warrant further investigations for underlying mechanisms.

• 出版日期2011-7
• 单位南京医科大学