科研之友
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摘要
The synthesis of a series of 6,6-bisbenzannulated spiroketals containing a 3H,3'H-2,2'-spirobi(benzo[b][1,4]dioxine) ring system is reported. The key step involves addition of a monobenzyl-protected catechol to the epoxide unit of a glycidol bearing a benzyl-protected catechol. The resultant alcohol adduct is oxidized to a ketone that then undergoes hydrogenation and acid-catalyzed cyclization to produce the desired spirodioxines.
- 出版日期2007-5-4
