A new lactam alkaloid from Portulaca oleracea L. and its cytotoxity

作者：Zhao, Chengcheng; Ying, Zheming; Tao, Xiaojun; Jiang, Mingyue; Ying, Xixiang^*; Yang, Guanlin^*

来源：Natural Product Research, 2018, 32(13): 1548-1553.

DOI：10.1080/14786419.2017.1385022

• Portulaca oleracea L
• alkaloid
• NMR
• cytotoxicity

A new lactam alkaloid named oleraciamide D (1), indentified as (5R)-4-(3-methoxy-4-hydroxyphenyl)-5-(4-hydroxyphenyl)-5,6-dihydropyridin-2(1H)-one, together with five known compounds, indole-3-aldehyde (2), portulacatone (3), N-trans-feruloyloctopamine (4), N-trans-feruloyl-3-O-methyldopamine (5) and N-trans-feruloyltyramine (6) were isolated from Potulaca oleracea L. Among them, indole-3-aldehyde (2) was isolated from the medicine for the first time. The structure of the new alkaloid was elucidated via UHPLC-ESI-Q-TOF/MS, 1D NMR and 2D NMR. The five known compounds were established by comparing the H-1-NMR and C-13 NMR with the reported literature. Oleraciamide D (1) showed cytotoxicity against SH-SY5Y cells when concentration at 50 uM by CCK-8 method.
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• 出版日期2018
• 单位辽宁中医药大学