A double oxidation procedure for the preparation of halogen-substituted para-benzoquinone monoketals: asymmetric synthesis of (-)-harveynone

作者：Hookins Daniel R; Taylor Richard J K^*

来源：Tetrahedron Letters, 2010, 51(50): 6619-6621.

DOI：10.1016/j.tetlet.2010.10.047

The double oxidation of halophenols with hypervalent iodine reagents in methanol provides a simple procedure to prepare halo-1,4-benzoquinone monoketals. Seven examples of this procedure are reported as is the conversion of 3-iodo-4,4-dimethoxycyclohexa-2,5-dienone into the natural product, (-)-harveynone.