An Imagable and Photothermal "Abraxane-Like" Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors

作者：Chen, Qian; Liang, Chao; Wang, Chao; Liu, Zhuang^*

来源：Advanced Materials, 2015, 27(5): 903-910.

DOI：10.1002/adma.201404308

• human serum albumin
• indocyanine green
• paclitaxel
• combination therapy
• lung metastasis

A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-ofconcept study.

• 出版日期2015-2-4
• 单位苏州大学