A New Cytotoxic Pregnanone from Calotropis gigantea

作者:Wang Zhu Nian; Wang Mao Yuan; Mei Wen Li; Han Zhuang; Dai Hao Fu*
来源:Molecules, 2008, 13(12): 3033-3039.
DOI:10.3390/molecules13123033

摘要

A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.