Antiganglioside antibodies in Guillain-Barre syndrome and its related conditions

作者：Shahrizaila Nortina; Yuki Nobuhiro^*

来源：Expert Review of Neurotherapeutics, 2011, 11(9): 1305-1313.

DOI：10.1586/ERN.11.114

• antiganglioside antibodies
• Fisher syndrome
• Guillain-Barre syndrome

Guillain-Barre syndrome (GBS) is typically classified into two major subtypes: acute inflammatory demyelinating neuropathy and acute motor axonal neuropathy. Its most recognizable variant is Fisher syndrome. The last two decades have seen considerable advances in our understanding of GBS. Of note, various autoantibodies against ganglioside antigens have been identified and found to have significant associations with the axonal forms of GBS and Fisher syndrome. In this article, we discuss the different clinical presentations in GBS and the role of antiganglioside antibodies in their underlying pathogenesis. We also discuss the impact that antiganglioside antibodies have had in the development of experimental models and treatment modalities in GBS.

• 出版日期2011-9