Dietary Flaxseed Independently Lowers Circulating Cholesterol and Lowers It beyond the Effects of Cholesterol-Lowering Medications Alone in Patients with Peripheral Artery Disease.

作者：Edel Andrea L; Rodriguez Leyva Delfin; Maddaford Thane G; Caligiuri Stephanie P B; Austria J Alejandro; Weighell Wendy; Guzman Randolph; Aliani Michel^*; Pierce Grant N

来源：Journal of Nutrition, 2015, 145(4): 749-757.

DOI：10.3945/jn.114.204594

• flaxseed
• cholesterol lowering
• peripheral artery disease
• platelet aggregation
• statins

Background: Dietary flaxseed lowers cholesterol in healthy subjects with mild biomarkers of cardiovascular disease (CVD).
Objective: The aim was to investigate the effects of dietary flaxseed on plasma cholesterol in a patient population with clinically significant CVD and in those administered cholesterol-lowering medications (CLMs), primarily statins.
Methods: This double-blind, randomized, placebo-controlled trial examined the effects of a diet supplemented for 12 mo with foods that contained either 30 g of milled flaxseed [milled flaxseed treatment (EX) group; n = 581 or 30 g of whole wheat [placebo (PL) group; n = 52] in a patient population with peripheral artery disease (PAD). Plasma lipids were measured at 0, 1, 6, and 12 mo.
Results: Dietary flaxseed in PAD patients resulted in a 15% reduction in circulating LDL cholesterol as early as 1 mo into the trial (P= 0.05). The concentration in the FX group (2.1 +/- 0.10 mmol/L) tended to be less than in the PL group (2.5 +/- 0.2 mmoVL) at 6 mo (P= 0.12), but not at 12 mo (P= 0.33). Total cholesterol also tended to be lower in the FX group than in the PL group at 1 mo (11%, P = 0.05) and 6 mo (11%, P = 0.07), but not at 12 mo (P = 0.24). In a subgroup of patients taking flaxseed and CLM (n = 36), LDL-cholesterol concentrations were lowered by 8.5% 3.0% compared with baseline after 12 mo. This differed from the PL + CLM subgroup (n = 26), which increased by 3.0% 4.4% (P= 0.030) to a final concentration of 2.2 +/- 0.1 mmoVL.
Conclusions: Milled flaxseed lowers total and LDL cholesterol in patients with PAD and has additional LDL cholesterol lowering capabilities when used in conjunction with CLMs.

• 出版日期2015-4