Activation of T Cells: Releasing the Brakes by Proteolytic Elimination of Cbl-b

作者：Schmitz M Lienhard^*

来源：Science Signaling, 2009, 2(76): pe38.

DOI：10.1126/scisignal.276pe38

Activation of T lymphocytes relies on the simultaneous delivery of signals from the T cell receptor and co-receptors such as CD28. The absence of co-receptor signaling leads to a state of unresponsiveness called anergy, which prevents T cells from reacting against self antigens. The biochemical program that ensures the induction of anergy uses several mechanisms, including the synthesis of ubiquitin E3 ligases such as Cbl-b (Casitas B-lineage lymphoma). Because these E3 ligases function as gatekeepers to prevent the undesired activation of T cells, full and productive induction of the T cell response requires the restriction of these negative regulators by mechanisms that we are beginning to understand.

• 出版日期2009-6-23