科研之友
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摘要
Clinicians and patients desiring amenorrhea for therapeutic or social reasons will find continuous-use 90 mu g levonorgestrel/20 mu g ethinyl estradiol to be an attractive oral contraceptive dosing option. Although other formulations of oral contraceptives can be dosed in a continuous manner off -label, the convenience of a 28-day dose pack represents a major advance that will likely increase acceptability of the strategy. The availability of FDA-approved continuous-use 90 mu g levonorgestrel/20 mu g ethinyl estradiol will help mainstream continuous oral contraception in the same way that Preven (TM) and Plan B (R) helped legitimize and mainstream emergency contraception. Patients wishing to use continuous 90 mu g levonorgestrel/20 mu g ethinyl estradiol must recognize and accept that unscheduled breakthrough bleeding is typical during the first four to six cycles of use. Control of cycle-related symptoms may emerge as an off -label indication for use.
- 出版日期2008-3
