ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity

作者：Verges, Bruno^*; Adiels, Martin; Boren, Jan; Barrett, Peter Hugh; Watts, Gerald F.; Chan, Dick; Duvillard, Laurence; Soderlund, Sanni; Matikainen, Niina; Kahri, Juhani; Lundbom, Nina; Lundbom, Jesper; Hakkarainen, Antti; Aho, Serge; Simoneau-Robin, Isabelle; Taskinen, Marja-Riitta

来源：Journal of Clinical Endocrinology & Metabolism, 2016, 101(4): 1398-1406.

DOI：10.1210/jc.2015-3740

• APOLIPOPROTEIN-A-II
• DENSITY-LIPOPROTEIN METABOLISM
• CORONARY-HEART-DISEASE
• TRIGLYCERIDE-METABOLISM
• PLASMA-LIPOPROTEINS
• TRANSFER PROTEIN
• AII METABOLISM
• INSULIN
• FAT
• HYPERTRIGLYCERIDEMIA

Context: The metabolism of high-density lipoprotein (HDL) is severely impaired in individuals with abdominal obesity. However, the specific metabolism of apolipoprotein (apo)-A-II, the second major apolipoprotein of HDL, remains poorly known. The relationships between HDL apoA-II catabolism and other metabolic variables that may be modified in abdominal obesity, such as very low-density lipoprotein (VLDL) subspecies (VLDL1, VLDL2) kinetics, remain to be investigated.
Objectives: Our aim was to study the associations between apoA-II fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and apoA-I.
Design: We carried out a multicenter in vivo kinetic study using stable isotopes (deuterated leucine and glycerol) in 62 individuals with abdominal obesity.
Results: In a univariate analysis, apoA-II FCR was positively correlated with body mass index, sc fat, liver fat, apoA-I FCR, apoA-I production rate (PR), apoA-II pool, apoA-II PR, VLDL1-triglyceride PR, VLDL2-triglyceride PR, VLDL2-triglyceride (TG) FCR, and VLDL2-apoB FCR and negatively with HDL cholesterol to apoA-I ratio. After adjustment for apoA-I FCR, a strong positive correlation between apoA-II FCR and VLDL1-TG indirect FCR was observed (r = 0.520, P < .0001). In a multivariate analysis, apoA-II FCR was independently and positively associated with apoA-I FCR (P < .0001) and VLDL1-TG indirect FCR (P < .0001). Both variables explained 59.7% of the variability in apoA-II FCR.
Conclusions: We show that, in abdominally obese individuals, apoA-II FCR is positively and independently associated with both apoA-I FCR and VLDL1-TG indirect FCR. These data suggest that, in a condition of delayed VLDL1 catabolism, such as abdominal obesity, retention of apoA-II in the VLDL1 pool may occur, with an effect on apoA-II catabolism. The consequences of this link between VLDL1 catabolism and apoA-II catabolism remain to be determined.

• 出版日期2016-4