Anti-inflammatory Diterpene from Thyrsanthera suborbicularis

作者：Khiev Piseth; Oh Sei Ryang; Chae Hee Sung; Kwon Ok Kyoung; Ahn Kyung Seop; Chin Young Won; Lee Hyeong Kyu^*

来源：Chemical & Pharmaceutical Bulletin, 2011, 59(3): 382-384.

DOI：10.1248/cpb.59.382

• Thyrsanthera suborbicularis
• Euphorbiaceae
• rosane diterpenoid
• nitric oxide
• inducible nitric oxide synthase

Bioactivity-guided isolation on a n-hexane-soluble fraction of Thyrsanthera suborbicularis led to the isolation of a new rosane-type diterpene, 19-hydroxy-1(10), 15-rosadiene (1), along with three known compounds, taraxerol, acetyl aleuritolic acid, and spathulenol. The structures of isolated compounds were determined by interpretation of NMR spectroscopic data and mass spectrometry. Compound 1 demonstrated significantly inhibitory activity on nitric oxide production in RAW264.7 lipopolysaccharide (LPS)-activated mouse macrophages with an IC50 value of 2.91 mu g/ml via the suppression of inducible nitric oxide synthase (iNOS) mRNA expression.

• 出版日期2011-3