Antibiotic Indole Sesquiterpene Alkaloid from Greenwayodendron suaveolens with a New Natural Product Framework

作者:Williams Russell B*; Hu Jin Feng; Olson Krista M; Norman Vanessa L; Goering Matt G; O'; Neil Johnson Mark; Eldridge Gary R; Starks Courtney M
来源:Journal of Natural Products, 2010, 73(5): 1008-1011.
DOI:10.1021/np1001225

摘要

High-throughput natural products chemistry methods have led to the isolation of three new (1-3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC(90) of 4 mu g/mL.

  • 出版日期2010-5