Association between psoriasis and metabolic syndrome: a meta-analysis from 12 case control studies

作者：Jin, Jing-Ji; Zeng, San-Wu^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(9): 17933-17939.

• Psoriasis
• metabolic syndrome
• obesity
• hypertension
• meta-analysis

Objective: Numerous studies have evaluated the increased prevalence of comorbid diseases and risk factors in psoriatic patients, a meta-analysis was conducted to evaluate the correlation between psoriasis and metabolic syndrome. Methods: Studies on the correlation between psoriasis and metabolic syndrome were identified by searches of PubMed, EMBASE, Cochrane Library, Web of Science databases from 1980 to March, 2016. The pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated to assess the strength of association. Results: 12 case control studies with a total of 3831 psoriasis patients were included in this meta-analysis. The results showed that metabolic syndrome was more prevalent in psoriasis patients than in controls. The odds ratio (OR) was 2.07 (95% CI: 1.61-2.67, random effect model). In addition, among these studies, 7 and 11 studies evaluated the correlation between psoriasis and obesity and hypertension, and the result demonstrated that higher prevalence was found in the psoriasis patients, the OR were 1.64 (95% CI: 1.08-2.47, random effect model) and 2.24 (95% CI: 1.62-3.10, random effect model), respectively. No significant publication bias was found in the studies. Conclusions: Patients with psoriasis have a higher prevalence of metabolic syndrome and hypertension compared with the controls. However, more prospective, controlled and randomized studies still need to be performed in the future.

• 出版日期2016
• 单位天津市第一中心医院