A practical synthesis of 2-chloro-2 '-deoxyadenosine (Cladribine) from 2 '-deoxyadenosine

作者：Peng Yao^*

来源：Journal of Chemical Research, 2013, 37(4): 213-215.

DOI：10.3184/174751913X13618878756705

• 2-chloro-2 '-deoxyadenosine (Cladribine)
• practical synthesis
• nitration
• 2 '-deoxyadenosine

A practical synthesis of 2-chloro-2'-deoxyadenosine (Cladribine) from 2'-deoxyadenosine is reported. Treatment of fully protected 2'-deoxyadenosine with 2,2,2-trifluoroacetic anhydride and tetrabutylammonium nitrate gave protected 2-nitro-2'-deoxyadenosine with high yield. 2-Chloro-2'-deoxyadenosine was synthesised in four steps and 44.8% yield after substitution by chloride and deprotection steps.

• 出版日期2013-4
• 单位新乡学院