A short enantioselective total synthesis of (R)- and (S)-pipecolic acid

作者：Chavan Subhash P^*; Khairnar Lalit B; Chavan Prakash N; Kalbhor Dinesh B

来源：Tetrahedron: Asymmetry , 2014, 25(16-17): 1246-1251.

DOI：10.1016/j.tetasy.2014.08.001

A convenient and practical total synthesis of (R)- and (S)-pipecolic acid has been achieved by utilizing chiral cis-aziridine-2-carboxylate as the common synthetic precursor. The synthesis involves regioselective reductive cleavage of the aziridine ring and Wittig olefination as key reactions.

• 出版日期2014-9-15