A unique turn-off fluorescent strategy for sensing dopamine based on formed polydopamine (pDA) using graphene quantum dots (GQDs) as fluorescent probe

作者：Weng, Shaohuang; Liang, Dong; Qiu, Huazhang; Liu, Zongen; Lin, Zhen; Zheng, Zongfu^*; Liu, Ailin; Chen, Wei; Lin, Xinhua

来源：Sensors and Actuators B: Chemical , 2015, 221: 7-14.

DOI：10.1016/j.snb.2015.06.093

• Dopamine detection
• Graphene quantum dots
• Fluorescent sensor
• Polydopamine
• Serum

A rapid, facile fluorescence sensing strategy was developed for dopamine (DA) detection based on poly-dopamine (pDA) formed on the surface of graphene quantum dots (GQDs). The prepared GQDs were strongly luminescent because of the aromatic planar structure. DA could self-polymerize to pDA and snap to the surface of GQDs to form a thin film in alkaline environment, leading to quenching of fluorescence due to fluorescence resonance energy transfer (FRET). With the optimized conditions, the analytical performance illustrated high sensitivity, selectivity in a wide linear range with a detection limit of 8 nM. In addition, the unique method was successfully applied for DA injection test with satisfactory labeled amount. Finally, the proposed strategy was applied for DA detection in serum, wherein accurate results were obtained.

• 出版日期2015-12-31
• 单位福建医科大学; 厦门大学