Association of pollution and climate with atopic eczema in US children

作者：Kathuria P; Silverberg J I^*

来源：Pediatric Allergy and Immunology, 2016, 27(5): 478-485.

DOI：10.1111/pai.12543

• eczema prevalence
• eczema severity
• atopic dermatitis
• small-particle air pollution
• air pollutants
• nitrate
• nitrogen dioxide
• sulfate
• sulfur dioxide
• ozone
• particulate matter under 2
• 5 m
• particulate matter under 10 m
• climate
• relative humidity
• ultraviolet index
• air temperature
• pediatric
• children

BackgroundWe sought to determine the relationship between childhood eczema, climate, and environmental pollutants.
MethodsWe analyzed data from the 2007-2008 National Survey of Children's Health including a representative sample of 91,642 children age 0-17 years and the 2006-2007 Environmental Protection Agency measurements of carbon monoxide (CO), nitrate (NO3), nitrogen dioxide (NO2), organic carbon (OC), sulfate (SO3), sulfur dioxide (SO2), particulate matter 2.5 m (PM-2.5) and <10 m (PM-10), and tropospheric ozone levels, and the National Climate Data Center measurements of relative humidity (%), issued UV index, outdoor air temperature, and precipitation levels.
ResultsIn multivariate survey logistic regression models controlling for age, sex, race/ethnicity, household income, US birthplace, and history of moving to a new location, eczema was associated with higher mean annual NO2 (p = 0.008), SO2 (p = 0.006), SO3 (p = 0.0002), arsenic (p = 0.0007), nickel (p = 0.0002), lead (p = 0.03), vanadium (p < 0.0001), and zinc (p = 0.003), but lower NO3 (p = 0.002), OC (p = 0.03), PM-2.5 (p = 0.006), cadmium (p < 0.0001), copper (p = 0.004), and potassium (p < 0.0001). In contrast, moderate-severe eczema was associated with higher NO3 (p = 0.03), OC (p = 0.008) and PM-2.5 (p = 0.01), copper (p = 0.04), lead (p = 0.008), and zinc (p = 0.01), but lower CO (p = 0.03). Principal component analysis was used and identified 4 combinations of pollutants and climate factors occurring in the USA, of which 1 was associated with higher prevalence and two were associated with lower prevalences of eczema (p < 0.05).
ConclusionsPollutants in conjunction with climate factors may differentially impact eczema prevalence and severity, some with apparent harmful effects.

• 出版日期2016-8
• 单位西北大学