科研之友
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摘要
By combining three kinds of DNA hairpins (one involving both aptamer sequence and trigger sequence, and the other two to amplify the signal by hybridization chain reaction), a food toxin ochratoxin A (OTA) was selectively detected with a remarkably high sensitivity. The signal was visualized with the use of the peroxidase-like function of G-quadruplexes that were formed from the terminal sequences of two adjacent fragments in the DNA nanowire. Even 0.08 ppb of OTA was successfully detected.
