科研之友
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摘要
Objective: The objective of this study was to investigate the association of receptor for advanced glycation end products (RAGE) gene polymorphisms and the risk of diabetic nephropathy (DN). Methods: Genotypes of RAGE gene polymorphisms (rs1800624, rs1800625 and rs2070600) were genotyped by MassArray method. Hardy-Weinberg equilibrium (HWE) was utilized to detect the representative of the cases and controls. Genotype and allele frequencies were obtained by direct calculation. Differences of genotypes and alleles of the polymorphisms between the case and control groups were assessed by Chi-square test. SPSS 18.0 was used to carry out all of the calculations. Results: Genotype and allele frequencies of rs1800624, rs1800625 and rs2070600 were higher in type I DN group that in control group, but the differences were not significantly (P>0.05). In type II diabetic patients, rs1800624 and rs1800625 polymorphisms were not related to the occurrence of DN (P>0.05). A allele of rs2070600 polymorphism might act as a risk factor for the development of DN in type II diabetic patients (P=0.032, OR=1.520, 95% CI=1.036-2.229). In the total DN patients (both in type I and type II DM) no significant association was observed in rs1800624 polymorphism and the development of DN. But both C and A alleles of rs1800625 and rs2070600 were significantly related to the susceptibility of DN (P=0.030, OR=1.515, 95% CI=1.040-2.209; P=0.043, OR=1.405, 95% CI=1.010-1.956). Conclusion: Rs1800624 was not related to the development of DN. RAGE rs1800625 and rs2070600 polymorphisms were associated with the total DN risk.
