Dangerous Entrapment for NRF2

作者：Gorbunova Vera^*; Rezazadeh Sarallah; Seluanov Andrei

来源：Cell, 2016, 165(6): 1312-1313.

DOI：10.1016/j.cell.2016.05.061

Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.

• 出版日期2016-6-2