A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study

作者：Nakagawa Senda Hiroko; Hachiya Tsuyoshi; Shimizu Atsushi; Hosono Satoyo; Oze Isao; Watanabe Miki; Matsuo Keitaro; Ito Hidemi; Hara Megumi; Nishida Yuichiro; Endoh Kaori; Kuriki Kiyonori; Katsuura Kamano Sakurako; Arisawa Kokichi; Nindita Yora; Ibusuki Rie; Suzuki Sadao; Hosono Akihiro; Mikami Haruo; Nakamura Yohko; Takashima Naoyuki; Nakamura Yasuyuki; Kuriyama Nagato; Ozaki Etsuko; Furusyo Norihiro; Ikezaki Hiroaki; Nakatochi Masahiro; Sasakabe Tae; Kawai Sayo

来源：Scientific Reports, 2018, 8(1): 1493.

DOI：10.1038/s41598-018-19914-w

Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 x 10(-6)). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 x 10(-6)), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A metaanalysis of the discovery and replication populations, and the combined analysis using all subjects,

• 出版日期2018-1-24