Analysis of Chloramphenicol in Drinking Water Using an Evaporation Preparative Step and Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry

作者：Li, Yonggang; Liu, Xiaohong; Zhang, Rui; ZomPa, DerGer; Luo, Ping; Tang, Lin; Liu, Xiao; Zhou, Yan; Wen, Sheng^*

来源：Acta Chromatographica, 2018, 30(1): 17-20.

DOI：10.1556/1326.2017.28404

• UHPLC-MS/MS
• chloramphenicol
• evaporation
• isotope dilution
• drinking water

A reliable isotope dilution method for the determination of chloramphenicol (CAP) in drinking water was developed by using an evaporation preparative step. Each sample was monitored by ultrahigh-pressure liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS/MS) using an electrospray ionization interface (ESI) in negative ion modes. Recoveries of spiked samples were in the range from 93.2% to 95.7% with intra-day relative standard deviation lower than 6.7% and inter-day relative standard deviation lower than 8.2%. Limit of quantification (LOD) was 0.002 ng/mL. The developed method was successfully applied to the analysis of CAP in drinking water of Shannan region of Tibet.

• 出版日期2018-3
• 单位湖北省疾病预防控制中心