A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells

作者：Lou, Li-Li; Zhao, Peng; Cheng, Zhuo-Yang; Guo, Rui; Yao, Guo-Dong; Wang, Xiao-Bo; Huang, Xiao-Xiao^*; Song, Shao-Jiang^*

来源：Natural Product Research, 2019, 33(12): 1791-1793.

DOI：10.1080/14786419.2018.1434646

• Juglans mandshurica
• coumarin
• cytotoxicity
• apoptosis
• hepatocellular carcinoma

In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 mu M. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.
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• 出版日期2019-6-18
• 单位沈阳药科大学