科研之友
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摘要
Rationale: Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplastic entity with a tendency of local recurrence and a low risk of distant metastasis. Involvement of trachea is extremely rare. Patient concerns: A 34-week pregnant woman previously diagnosed with asthma for 2 months was admitted with persistent wheezing and hemoptysis. A computed tomography scan and bronchoscopy revealed a gigantic polyp in the trachea. Diagnoses: Tracheal inflammatory myofibroblastic tumor. Interventions: The mass was removed with an electrocautery snare and identified histologically as an IMT. Further immunochemical staining showed strong positive staining for smooth muscle actin and platelet-derived growth factor receptor a (PDGFRA), weak positive staining for caldesmon, and negative staining for anaplastic lymphoma kinase (ALK) 1, desmin, S-100, and CD34. The tracheal IMT strongly expressed estrogen receptor-a (ER-a), which indicated that the development of this rare IMT might have been associated with hormone fluctuations that occurred during the pregnancy. Outcomes: Follow-up and histological analyses revealed no evidence of recurrence and metastasis. Lessons: This report describes an extremely rare case of a tracheal IMT that presented a diagnostic dilemma for the clinician and the pathologist. Tracheal IMT is a challenge for the clinician in diagnosis due to the nonspecific clinical presentation. Histology and immunohistochemistry are required to reach an accurate diagnosis of IMT.
- 出版日期2017-8
- 单位华中科技大学
