A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C-H insertion

作者:Lepage Romain J; White Jonathan M; Coster Mark J*
来源:Chemical Communications, 2017, 53(30): 4219-4221.
DOI:10.1039/c7cc00459a

摘要

Acyclicmethylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals VIA bidirectional C-H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).

  • 出版日期2017-4-18