Adipose tissue compartments, muscle mass, muscle fat infiltration, and coronary calcium in institutionalized frail nonagenarians

作者：Idoate Fernando; Cadore Eduardo L; Casas Herrero Alvaro; Zambom Ferraresi Fabricio; Marcellan Teresa; de Gordoa Ana Ruiz; Rodriguez Manas Leocadio; Bastarrika Gorka; Marques Mario C; Martinez Velilla Nicolas; Vicente Campos Davinia; Izquierdo Mikel^*

来源：European Radiology, 2015, 25(7): 2163-2175.

DOI：10.1007/s00330-014-3555-5

• Adipose tissue
• Frailty
• Muscle quality
• Coronary calcium
• Muscle fat infiltration

to compare the different adipose tissue (AT) compartments, muscle mass, muscle fat infiltration, coronary calcium, as well as associations among changes in different AT compartments between frail and robust nonagenarians.
Forty-two elderly subjects took part in this study: 29 institutionalized frail elderly (92.0 +/- 8 years) and 13 robust elderly (88.2 +/- 4.1 years). All patients underwent helical thoracic, abdominal and thigh computed tomography (CT). In addition, a non-enhanced prospectively ECG-triggered cardiac CT was performed to quantify the amount of coronary artery calcification and measure pericardial AT.
The robust group presented significantly greater pericardial and abdominal AT volume, as well as greater axial and appendicular muscle size and high-density muscle tissue (greater muscle quality) than the frail group (P < 0.001), whereas no differences between groups were observed in coronary calcium. There were positive correlations between pericardial AT with visceral and subcutaneous AT values, as well as between pericardial AT and quadriceps, hamstrings, psoas and paravertebral low-density muscle tissues in the frail and robust groups (r = 0.57 to 0.91,P < 0.05).
Robust group presented greater muscle size and quality in the axial and appendicular muscles, as well as pericardial and abdominal AT area than the frail group.
aEuro cent Robust nonagenarians presented more pericardial and abdominal AT volume than frail.
aEuro cent Frailty is associated with lower muscle size and high-density muscle tissue.
aEuro cent Muscle-fat infiltration shares analogous pattern of visceral and pericardial AT distribution.

• 出版日期2015-7