Apolipoprotein A-I: the dual face of a protein

作者：Arciello Angela; Piccoli Renata; Monti Daria Maria

来源：FEBS LETTERS, 2016, 590(23): 4171-4179.

DOI：10.1002/1873-3468.12468

<jats:p>Conformational plasticity and flexibility are key structural features of Apo<jats:styled-content style="fixed-case">AI</jats:styled-content> in lipid metabolism. Amyloidogenic single point mutations, associated with incurable familial amyloidosis with fibril deposition in peripheral organs, may have a dramatic impact on the structural and functional features of Apo<jats:styled-content style="fixed-case">AI</jats:styled-content>. Here, the consistent body of data on Apo<jats:styled-content style="fixed-case">AI</jats:styled-content> variants has been reviewed, with the aim of highlighting the hallmarks of the pathology. In accordance with our observations, as well as that of others, we propose a model that accounts for the alteration of the delicate balance between lipid‐free/lipid‐bound dynamic states which is based on monomer‐to‐dimer interconversion <jats:italic>via</jats:italic> domain swapping.</jats:p>

• 出版日期2016-12