Absence of gender effect on amygdala volume in temporal lobe epilepsy

作者：Silva Ivaldo^*; Lin Katia; Jackowski Andrea P; Centeno Ricardo da Silva; Pinto Magali L; Carrete Henrique Jr; Yacubian Elza M; Amado Debora

来源：Epilepsy and Behavior, 2010, 19(3): 501-503.

DOI：10.1016/j.yebeh.2010.08.031

• Temporal lobe epilepsy
• Mesial temporal lobe sclerosis
• Gender
• Amygdala
• Magnetic resonance imaging

Sexual dimorphism has already been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). This study evaluated the effect of gender on amygdala volume in patients with TLE-MTS. One hundred twenty-four patients with refractory unilateral or bilateral TLE-MTS who were being considered for epilepsy surgery underwent a comprehensive presurgical evaluation and MRI. Amygdalas of 67 women (27 with right; 32 with left, and 8 with bilateral TLE) and 57 men (22 with right, 30 with left, and 5 with bilateral TLE) were manually segmented. Significant ipsilateral amygdala volume reduction was observed for patients with right and left TLE. No gender effect on amygdala volume was observed. Contralateral amygdalar asymmetry was observed for patients with right and left TLE. Although no gender effect was observed on amygdala volume, ipsilateral amygdala volume reductions in patients with TLE might be related to differential rates of cerebral maturation between hemispheres.

• 出版日期2010-11