摘要
Despite over 15 years of research, the exact role, if any, played by estrogen receptor beta (ER beta) in human breast cancer remains elusive. A large body of data both in vitro and in vivo supports its role as an antiproliferative, pro-apoptotic factor especially when co-expressed with ER alpha. However, there is a smaller body of data associating ER beta with growth and survival in breast cancer. In clinical studies and most often in cell culture studies, the pro-growth and pro-survival activity of ER beta occurs in ER alpha-negative breast cancer tissue and cells. This bi-faceted role of ER beta is discussed in this review.
- 出版日期2013-6