Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-alpha and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

作者：Lomakin Yakov; Belogurov Alexey Jr; Glagoleva Irina; Stepanov Alexey; Zakharov Konstantin; Okunola John; Smirnov Ivan; Genkin Dmitry; Gabibov Alexander

来源：Mediators of Inflammation, 2016, 2016: 2847232.

DOI：10.1155/2016/2847232

have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients. We observed a statistically significant decrease of MCP-1/CCL2, MIP-1 beta/CCL4, IL-7, and IL-2 at the time of study completion. In contrast, the serum levels of TNF-alpha were remarkably elevated. Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects. These data are an important contribution for the upcoming Xemys clinical trials.

• 出版日期2016