An efficient protocol for the one-pot four-component synthesis of 6-amino-1, 4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using starch solution as a reaction media

作者：Vekariya Rajesh H.; Patel Kinjal D.; Patel Hitesh D.^*

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2018, 57(4): 576-582.

• Pyrano[2,3-c]-pyrazoles
• starch solution
• one-pot synthesis
• multi-component reaction

An efficient, high-yielding and rapid protocol has been developed for the synthesis of 6-amino-1,4-dihydropyrano [2,3-c]pyrazol-5-carbonitrile derivatives through four-component, one-pot cyclocondensation reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes and malononitrile utilizing starch solution as a highly efficient homogenous catalyst. The use of a nontoxic, reusable and biodegradable catalyst is one of the superior advantagesof this protocol. Short reaction times, mild conditions, excellent product yields, simple work-up procedure and non use of toxic organic solvents are added advantages of this procedure.

• 出版日期2018-4