Association between arsenic metabolism gene polymorphisms and arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China

作者：Luo, Lanrong; Li, Yuanyuan; Gao, Yanhui; Zhao, Lijun; Feng, Hongqi; Wei, Wei; Qiu, Chuanying; He, Qian; Zhang, Yanting; Fu, Songbo^*; Sun, Dianjun^*

来源：Scientific Reports, 2018, 8(1): 413.

DOI：10.1038/s41598-017-18925-3

• PURINE NUCLEOSIDE PHOSPHORYLASE
• DRINKING-WATER
• OXIDATIVE STRESS
• BLADDER-CANCER
• SUSCEPTIBILITY
• METHYLATION
• AS3MT
• HEALTH
• GSTO
• RISK

Individuals in a given environment contaminated with arsenic have different susceptibilities to disease, which may be related to arsenic metabolism, age, gender, genetics and other factors. This study recruited 850 subjects, including 331 cases and 519 controls, from populations exposed to high levels of arsenic in drinking water in northwest China. Genotypes were determined using a custom-by-design 48-Plex GSTO1 GSTO1 rs2164624, at least one A allele for GSTO1 GSTO2 rs156697, the AG genotype or at least one G allele for GSTO2 GSTO1, GSTO2 and PNP render the susceptible toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.

• 出版日期2018-1-11
• 单位哈尔滨医科大学; 中国疾病预防控制中心