ALLELE-SPECIFIC GENE PROBING SUPPORTS THE DQ MOLECULE AS A DETERMINANT OF INHERITED SUSCEPTIBILITY TO TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS

作者：JENKINS D; MIJOVIC C; JACOBS KH; PENNY MA; FLETCHER J; BARNETT AH

来源：Diabetologia, 1991, 34(2): 109-113.

DOI：10.1007/BF00500381

• TRANSRACIAL STUDIES
• NORTH INDIANS
• GENE PROBING, HLA-DQ
• TYPE-1 (INSULIN-DEPENDENT) DIABETES

Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabetic and control subjects of North Indian origin supported the DQw1.18 allele of the DQB1 gene as a determinant of inherited protection against Type 1 diabetes (RR = 0.12, p(c) < 0.05). The A3 allele of the DQA1 gene was positively associated with the disease, (RR = 3.6, p(c) < 0.05), as was the DQw2 allele of the DQB1 gene (RR = 4.

• 出版日期1991-2