Anti-GQ1b-Negative Miller Fisher Syndrome After Campylobacter jejuni Enteritis

作者：Lee Kyung Yeon^*

来源：Pediatric Neurology, 2012, 47(3): 213-215.

DOI：10.1016/j.pediatrneurol.2012.04.024

Miller Fisher syndrome is a clinical variant of Guillain-Barre syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia. It results from an immune response to a cross-reactive antigen between GQ1b ganglioside in human neurons and lipooligosaccharides of certain bacteria, e.g., Campylobacter jejuni. Anti-GQ1b antibody is a powerful diagnostic marker for Miller Fisher syndrome. However, only a small number of anti-GQ1b-negative Miller Fisher syndrome cases are documented. A 13-year-old boy demonstrated typical clinical features of Miller Fisher syndrome 1 week after C. jejuni enteritis, but was anti-GQ1b and anti-GM1b antibody-negative.

• 出版日期2012-9