Accidental fatal aflatoxicosis due to contaminated commercial diet in 50 dogs

作者：Bruchim Y^*; Segev G; Sela U; Bdolah Abram T; Salomon A; Aroch I

来源：Research in Veterinary Science, 2012, 93(1): 279-287.

DOI：10.1016/j.rvsc.2011.07.024

• Canine
• Disseminated intravascular coagulation
• Intoxication
• Aflatoxin
• Liver failure

Aflatoxins, produced by Aspergillus spp., are toxic contaminants of stored grain. This study describes 50 dogs presented with foodborne aflatoxicosis. Common clinical signs included lethargy (78%), vomiting (76%), anorexia (74%), icterus (66%), depression (66%), melena (60%), haematuria (36%) and diarrhoea (36%). Common laboratory abnormalities included increased activities of aspartate aminotransferase (86%), alkaline phosphatase (84%) and alanine aminotransferase (79%), hypoantithrombinaemia (86%), prolonged prothrombin (PT, 82%) and activated partial thromboplastin times (aPTT, 80%), hyperbilirubinaemia (73%), hypocholesterolaemia (60%) hypoalbuminemia (47%) and thrombocytopenia (42%). Non-survivors had longer PT and aPTT and lower antithrombin (P < 0.001) at presentation compared to survivors (23.8 s vs. 10.5; 37.9 vs. 17.6s and 5% vs. 54%, respectively). Hyperbilirubinaemia (>56.6 mu mol/L) and albumin concentration <32.5 g/L at presentation were risk factors for mortality (P < 0.0001). Common complications included disseminated intravascular coagulation (58%), hepatic encephalopathy (35%) and acute kidney injury (4%). The mortality rate was 68%, suggesting that dogs with aflatoxicosis have poor prognosis.

• 出版日期2012-8