Neuropsychiatric Symptoms in Mild Dementia with Lewy Bodies and Alzheimer's Disease

作者：Bjoerke Bertheussen J^*; Ehrt U; Rongve A; Ballard C; Aarsland D

来源：Dementia and Geriatric Cognitive Disorders, 2012, 34(1): 1-6.

DOI：10.1159/000339590

• Dementia
• Dementia with Lewy bodies
• Alzheimer's disease
• Neuropsychiatric inventory
• Psychiatric symptoms
• Delusion
• Hallucinations
• Apathy

Background/Aims: To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Methods: Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups using non-parametric tests. Results: The DLB patients had a higher NPI total score (median 24 vs. 11.5, p < 0.005), more numerous symptoms (median 5 vs. 4, p = 0.001) and more clinically significant symptoms (3 vs. 1, p = 0.001). They also had higher item hallucinations (6 vs. 2, p < 0.005) and apathy (7 vs. 5, p = 0.002) subscores. Caregivers scored higher on the NPI total caregiver distress scale (12.5 vs. 6, p = 0.003). Conclusions: In mild dementia, DLB patients have more neuropsychiatric symptoms and more associated caregiver distress compared with AD.

• 出版日期2012