Mechanistic Studies on a Cu-Catalyzed Aerobic Oxidative Coupling Reaction with N-Phenyl Tetrahydroisoquinoline: Structure of Intermediates and the Role of Methanol As a Solvent

作者：Boess Esther; Sureshkumar Devarajulu; Sud Abhishek; Wirtz Cornelia; Fares Christophe; Klussmann Martin^*

来源：Journal of the American Chemical Society, 2011, 133(21): 8106-8109.

DOI：10.1021/ja201610c

The mechanism of an aerobic copper-catalyzed oxidative coupling reaction with N-phenyl tetrahydroisoquinoline was investigated. The oxidized species formed from the reaction of the amine with the copper catalyst were analyzed by NMR-spectroscopy. An iminium dichlorocuprate was found to be the reactive intermediate and could be structurally characterized by X-ray crystallography. The effect of methanol to effectively stabilize the iminium ion was investigated and shown to be beneficial in an oxidative allylation reaction.

• 出版日期2011-6-1